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One of the toughest challenges in halting or reversing the autoimmune process that destroys beta cells and causes type 1 diabetes is doing so in a way that does not compromise a person’s entire immune system. Antigen-specific immune therapy research, which targets only a specific part of the immune...

In our efforts to cure T1D, JDRF actively supports research aimed at restoring a person's insulin-producing capability and halting or reversing the body's misguided immune attack on the pancreas. A cure for T1D remains JDRF’s key priority and in the past month or so, a couple of JDRF cure...

In June, the Centers for Disease Control and Prevention (CDC) and the National Institutes of Health (NIH) released results from their latest SEARCH for Diabetes in Youth study . The data revealed a 23 percent growth in type 1 diabetes (T1D) prevalence, between 2001 and 2009, in Americans under age 20...

Diabetic neuropathy , or nerve damage, is one of the most painful complications faced by people with diabetes. Over time, high blood sugar associated with diabetes may lead to nerve damage. In the legs and feet, this nerve damage frequently results in numbness or lack of sensation, but it can also lead...

Replacing the body’s insulin-producing beta cells is one potential method for curing type 1 diabetes (T1D). Researchers are attempting to solve a number of challenges to make beta cell replacement a reality. These include: overcoming the misguided immune system attack on these cells that causes...

Nearly 20 years ago, the Diabetes Control and Complications Trial (DCCT) proved that keeping tight control over blood sugar levels can help prevent or delay the onset of complications for people with diabetes. Since then, researchers have continued to study complications with the goal of discovering...

As new cases of type 1 diabetes (T1D) increase worldwide , JDRF has continued to focus on preventing T1D in those at risk. By the time symptoms of T1D appear, however, the destruction of insulin producing beta cells may have already been occurring for some time. In order to effectively prevent the disease...

Researchers from the Salk Institute have identified molecular switches that regulate islet beta cell survival and insulin production. These findings could help lead to development of new diabetes drugs. The JDRF-funded Salk researchers, led by Dr. Marc Montminy, focused on glucagon-like peptide-1 (GLP...

In the 1990's, a groundbreaking study known as the Diabetes Control and Complications Trial (DCCT) showed that, for people with type 1 diabetes, intensive blood sugar control lowers the risk of developing complications. Specifically, the study showed that tight blood sugar control could reduce the...

Last week, the National Institutes of Health (NIH) announced a plan outlining their diabetes research strategy over the next decade that will aim to benefit Americans living with, or at risk for diabetes and its complications. At a time when the incidence of type 1 and type 2 diabetes is rising, this...

JDRF's Industry Drug and Development Partnership (IDDP) program is an integral part of the organization's overall strategy to address the gaps that currently exist in ongoing research to develop better treatments and cures for type 1 diabetes. Our collaborations with industry are designed to...

T cells are a type of white blood cell that play an important role in the immune system and help control infections. In a person with type 1 diabetes, however, T cells mistakenly attack and destroy the body’s own insulin-producing beta cells. In a new study published in the current issue of the...

A JDRF-funded study involving people who have lived with type 1 diabetes confirmed that insulin-producing beta cells can survive in people with diabetes – even after living with the disease for decades. Research by the Joslin Diabetes Center in Boston “firmly established” that some...

Islet transplantation has shown potential to restore insulin production in people with type 1 diabetes in recent years. Two main hurdles, however, prevent islet transplantation from being a more successful and widespread procedure: the use of chronic immunosuppressive drugs to prevent rejection and autoimmunity...